sequence-binding protein
نویسندگان
چکیده
Vol. 203, No. 1, January 23, 2006 63–72 www.jem.org/cgi/doi/10.1084/jem.20051450 63 The response of peripheral B cells to Tdependent antigen involves a highly orchestrated series of changes. These are manifested by successive alterations in responsiveness to external signals, anatomic relocalization with pas sage through the germinal center (GC), modifi cations in Ig genes by somatic hypermutation (SHM) and class switch recombination (CSR), and the assumption of alternative fates as longlived memory cells or Ig-secreting plasma cells (1). This multistep process of diff erentiation is governed by an interlocking chain of transcrip-
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